Evidence for the LDL hypothesis raises new questions

In an article published on June 3, scientists have provided the best evidence yet that lowering low-density lipoprotein (LDL) levels improves cardiovascular health. The IMPROVE-IT trial helps to resolve a long-standing debate around the hypothesis that lowering LDL alone accounts for improved outcomes for patients taking statins. The alternative hypothesis posits that the effects of statins depend not only on lowering LDL, but also on unknown mechanisms.
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