Japanese Circulation Society

IS110: Lipid Lowering as an Anti-inflammatory Therapy on Vulnerable Atherosclerotic Plaques
Masanori Aikawa, M.D., Ph.D.

Figure 2. Oxidative stress appears to be able to decrease the expression of endothelial nitric oxide synthase by endothelial cells. Decreased eNOS should promote macrophage-rich atheroma formation, since eNOS can limit the monocyte-endothelial cell interaction. (ROS, reactive oxygen species; LDL, low density lipoprotein; EC, endothelial cell, eNOS, endothelial nitric oxide synthase; VCAM, , vascular cell adhesion molecule; MCP, monocyte chemoattractant.) (Aikawa 2000)