Japanese Circulation Society

Keynote Lecture: Cell Cycle Regulation and Myocardial Regeneration?
Harold S. Bernstein, M.D., Ph.D.

Figure 2. CDC2-cyclin B (CLNB) comprises the cyclin dependent kinase complex that drives the G2/M transition of the cell cycle. This complex is regulated through phosphorylation and de-phosphorylation events carried out by Wee1 and Myt1 kinases, Cdc25C phosphatase, and the CDK7-cyclin H (CLNH) complex. Although upstream regulators of these phosphatases and kinases are known, the transcriptional regulation of these events is not well understood. (Harold Bernstein April 2000)