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IS058: Diabetes, PAI-1, and Atherogenesis
David J. Schneider, M.D.
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| Figure 1. Schematic
of the relation between PAI-1 and atherogenesis. In the vessel
lumen, PAI-1is critical in the thrombolytic response to vascular
injury. In the vessel wall, PAI-1 appears to be critical in
atherogenesis by impairing cell-surface proteolysis, mediated
primarily by urokinase type plasminogen activator (u-PA). (Schneider
2000) |
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