Japanese Circulation Society

IS097: Keynote Lecture Signaling Events in Cardiomyocyte Dropout
Gerald W. Dorn II, M.D.

Figure 2. In vivo hemodynamic analysis measuring left ventricular (LV) dv/dt as a function of isoproterenol infused showed a parallel increase in isoproterenol dose and LV contractile function. Basal LV function was maximal in the lower level overexpressers. In the higher level overexpressers, at 12 weeks basal function was enhanced over non-transgenic with no response to isoproterenol and function was diminished with high levels of isoproterenol. At 20 weeks, the functional decline was even more enhanced. Basal function was essentially normal, with no response to isoproterenol. (Dorn 2000)