Figure 3. The survival curve from the longitudinal analysis showed that at about 11 weeks, the 350-fold overexpressers began to die, and all were dead by 35 weeks (top panel). Molecular analysis using RNA dot blot expression of hypertrophy-associated genes in a time course of 7, 11 and 17 week-old ß-2AR-350 animals revealed no molecular progression (bottom panel). The same molecular abnormalities of increased beta myosin heavy chain and atrial natriuretic factor expression were present in 7-week and 17-week old animals. (Dorn 2000)