Japanese Circulation Society

IS066 Keynote Lecture: Ischemic Preconditioning and Cardioprotection: Mechanisms by which Early (First Window) and Late (Second Window) Phases of Protection are Induced
James M. Downey, M.D.

Figure 2. The two selective tools for the mitochondrial K_ATP channel are diazoxide which opens the channel and 5 hydroxydecanoate (5HD) which closes it. Here intravenous diazoxide (DIAZ) mimics preconditioning when given as a pretreatment (PRE) in an open-chest rabbit and 5HD can block that protection. Note that diazoxide was not protective when given 10 min after ischemia had started (POST). (American Journal of Physiology 1999; 276:H1361-H1368.)