Japanese Circulation Society

IS106: Genetic Manipulation of Beta-adrenergic Signaling in the Failing Heart
Walter J. Koch, Ph.D.

Figure 2. ßAR density after subselective intracoronary delivery of Ad5/ß2 in the rabbit model. Overexpression is seen in the left ventricle and no expression in the right ventricle using left circumflex delivery. Higher levels of expression are obtained in the right ventricle using right coronary artery delivery. ß receptor overexpression in the range of 6- to 10-fold led to enhanced contractility of the rabbit heart at 7-21 days after gene delivery. (Circulation 2000;101:408-414.)

Reprinted with permission from Lippincott Williams and Wilkins (www.lww.com).