|
IS173: AMPD1 Genotype Predicts Survival in Patients
with Heart Failure
Evan Loh, M.D.
|
| |
AMPD1 +/-
or -/-
(n=21)
|
AMPD1 +/+
(n=111)
|
|
Age, y
|
56.8±7.1
|
52.1±11.6
|
| Sex,
n (%) |
|
|
Male
|
16
(79)
|
97
(89)
|
Female
|
5
(21)
|
14
(11)
|
| Cause,
n (%) |
|
|
CAD
|
8
(38)
|
55
(50)
|
IDCMP
|
11 (52)
|
38 (34)
|
Other
|
2
(10)
|
18
(16)
|
| Medical
therapy, n (%) |
|
|
Diuretics
|
19
(90)
|
99
(89)
|
Digoxin
|
15
(71)
|
103
(93)*
|
ACE inhibitor
|
18 (86)
|
93 (85)
|
| LVEF,
% |
18.9±7.4
|
19.9±6.9
|
| Cardiac
index, L · min-1 · m-2 |
1.8±0.6
|
1.8±0.8
|
| PCWP,
mm Hg |
21.6±10.9
|
22.0±9.0
|
| PVR,
Wood units |
2.9±2.1
|
2.9±2.4
|
| Vo2max,
mL · kg-1 · min-2 |
15.1±6.7
|
13.7±4.6
|
| Symptom
duration, y |
7.6±6.5
|
3.2±3.6*
|
CAD indicates coronary
artery disease; IDCMP, idiopathic dilated cardiomyopathy; LVEF,
left ventriclar ejection fraction; PCWP, pulmonary capillary
wedge pressure; and PVR, pulmonary vascular resistance.
* P<0.001; AMPD1 +/- or -/- vs AMPD1 +/+. All other
comparisons P>0.05
Plus/minus values are mean±SD. |
|
Copyright © 2000 Japanese
Circulation Society
All Rights Reserved.
webmaster@j-circ.or.jp
|
