Japanese Circulation Society

IS155: Genetic Dissection of Cardiac Life and Death Cascades
Michael D. Schneider, M.D.

Figure 2. TAK1 activity in myocardium in vivo is upregulated as a delayed response to aortic banding. Activation of a kinase as a delayed response following pressure overload is seen, consistent with its involvement in time-dependant autocrine-paracrine mechanisms Upregulation of TAK levels is not seen. (Nature Medicine 2000;6(5):556-562.)