Japanese Circulation Society

IS001 Keynote Lecture: Molecular Mechanisms Underlying Heterogeneities in Repolarization
Jeanne M. Nerbonne, M.D.

Figure 1. Action potential waveforms and propagation in the human heart. (A) Schematic of action potentials, recorded in different regions of the human heart, are displaced in time to reflect the temporal sequence of propagation. (B) Schematic of a ventricular action potential labelled as follows: (0) depolarization; (1) early (fast) repolarization; (2) plateau phase; (3) late (slow) phase of repolarization; and, (4) after hyperpolarization/return to the resting membrane potential. (SA, sino-atrial; AV-atrio-ventricular; RV, right ventricle; LV, left ventricle) (Journal of Physiology 2000;525(2):285-298).