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IS001 Keynote Lecture: Molecular Mechanisms Underlying Heterogeneities
in Repolarization
Jeanne M. Nerbonne, M.D.
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| Figure 2. Molecular
genetic dissection of the transient outward K+ currents,
Ito,f and Ito,s in mouse ventricular myocytes.
Representative outward K+ current waveforms recorded
from adult C57BL6 mouse left ventricular (LV) apex and septum
cells in response to 4.5 sec depolarizing voltage steps to -20
mV to +50 mV from a holding potential of -70 mV. Records from
wild type, Kv4.2W362F-expressing, Kv1.4-/- and Kv4.2W362F x
Kv1.4 -/- LV cells are illustrated. (Nerbonne 2000) |
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