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IS001 Keynote Lecture: Molecular Mechanisms Underlying Heterogeneities
in Repolarization
Jeanne M. Nerbonne, M.D.
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| Figure 3: QT prolongation
in mice lacking Ito,f,Ito,sor both Ito,f
and Ito,s.Left panel: Telemetric ECG recording were
obtained from conscious adult C57BL6 mice with the genotypes
indicated. Right panel: Variations in QT intervals with heart
rate in wild type, Kv4.2W362F-expressing, Kv1.4-/- and Kv4.2W362F
x Kv1.4 -/- LV cells are illustrated. (Nerbonne 2000) |
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