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IS001 Keynote Lecture: Molecular Mechanisms Underlying Heterogeneities
in Repolarization
Jeanne M. Nerbonne, M.D.
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Table 1. Voltage-Gated K+
Currents in the Mammalian Myocardium*
(Journal
of Physiology 2000;525(2):285-298)
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Current
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Activation
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Inactivation
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Blocker
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Cell Type
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Species
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Ito
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Ito,f
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fast
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fast
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mM 4-AP1
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atrial
|
dog, human, mouse, rat
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|
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Flecainide
|
ventricular
|
cat, dog, ferret, human, mouse, rat
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HaTX2
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Purkinje
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sheep
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HpTX3
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Ito,s
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fast
|
slow
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mM 4-AP
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atrial
|
rabbit
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| |
|
|
|
|
ventricular
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ferret, human, mouse, rabbit, rat
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Purkinje
|
rabbit
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nodal
|
rabbit
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IK
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IKr
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moderate
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fast
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E-4031
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atrial
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dog, guinea pig, human, rat
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|
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Dofetilide
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ventricular
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cat, dog, guinea pig, human,
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Lanthanum
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mouse, rabbit, rat
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Purkinje
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rabbit
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nodal
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rabbit
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IKs
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very slow
|
no
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NE-10064
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atrial
|
dog, guinea pig, human
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NE-10133
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ventricular
|
dog, guinea pig, human
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|
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Purkinje
|
rabbit
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|
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nodal
|
guinea pig, rabbit
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IKur
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fast
|
no
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m M
4-AP
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atrial
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dog, human, rat
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IKp
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fast
|
no
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Ba2+
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ventricular
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guinea pig
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IK
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slow
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slow
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mM TEA4
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ventricular
|
rat
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|
|
|
|
|
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IK,slow
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fast
|
slow
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mM 4-AP
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atrial
|
mouse
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|
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mM TEA
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ventricular
|
mouse
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IK,slow
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fast
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very slow
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mM 4-AP
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atrial
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human, rat
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(IK, DTX)
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a-DTX5
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Iss
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slow
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-
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mM TEA
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atrial
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mouse, rat
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mM 4-AP
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ventricular
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dog, human, mouse, rat
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*Voltage-gated
K+ currents identified to date in adult cells from
various species (see text). 14-AP= 4-Aminopyridine;
2HaTX= Hanatoxin; 3HpTX= Heteropodatoxin;
4TEA= Tetraethylammonium; 5a-DTX= a-Dendrotoxin
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Circulation Society
All Rights Reserved.
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