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IS001 Keynote Lecture: Molecular Mechanisms Underlying Heterogeneities
in Repolarization
Jeanne M. Nerbonne, M.D.
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Table 2. Kva Subunits: Relation
to Functional Voltage-Gated Cardiac K+ Currents
(Journal
of Physiology 2000;525(2):285-298)
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Family
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Subunit
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Activation*
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Inactivation*
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Blocker*
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Endogenous Current
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Kv1
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(Shaker)
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Kv 1.1
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Kv 1.2
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fast
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slow
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4-AP
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IK,slow (rat)
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DTX1
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(IK,DTX)
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Kv 1.3
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Kv 1.4
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fast
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slow
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4-AP
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Ito,s
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Kv 1.5
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fast
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slow
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4-AP
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IKur (human/rat)
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IK,slow (mouse)
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Kv 1.6
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Kv 1.7
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fast
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fast
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NTX2
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??
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Kv 1.8
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Kv2
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(Shab)
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Kv 2.1
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slow
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very slow
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TEA, HaTx3
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IK,slow (mouse)
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Kv 2.2
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slow
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very slow
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TEA
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??
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Kv3
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(Shaw)
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Kv 3.1
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fast
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slow
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TEA
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IKur (canine)
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Kv 3.2
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Kv 3.3
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Kv 3.4
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Kv4
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(Shal)
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Kv 4.1
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Kv 4.2
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fast
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fast
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4-AP, HaTx3, HpTx4
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Ito,f
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Kv 4.3
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fast
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fast
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4-AP, HpTx4
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Ito,f
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Kv5
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Kv 5.1
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coassemble with Kv2 Subunits
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_
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??
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Kv6_9
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eag family
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eag
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eag
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elk
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elk
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erg1
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erg1
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moderate
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fast
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E-4031
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IKr (with mirp)
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erg2
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erg3
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KvLQT1 family
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KCNQ1
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KvLQT1
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very slow
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very, very slow
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NE-10064
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IKs (with mink)
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KCNQ2
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KCNQ3
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*Properties determined for heterologously expressed subunits;
detailed properties, however, do vary with expression system
(see text). 
indicates cardiac expression; 1DTX= Dendrotoxin;
2NTX= Noxioustoxin; 3HaTX= Hanatoxin;
4HpTX= Heteropodatoxin.
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Circulation Society
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