Japanese Circulation Society

IS076: Preconditioning in Humans
Derek M. Yellon, M.D.

Figure 1. Human muscle subjected to 90 minutes of hypoxia and 2 hours of re-oxygenation had a 25% functional recovery (control). Muscle subjected to a 3-minute hypoxic insult and 7 minutes of re-oxygenation prior to the 90-minute insult had a significantly improved functional recovery (PC). CCPA, an adenosine analogue used in place of hypoxia, produced protection similar to that with preconditioning (rPIA). The protective effect of preconditioning was abolished in the presence of SPT (PC and SPT) and the adenosine receptor antagonist. SPT alone had no effect (SPT). (J Moll Cell Cardiol 1995;27;1349-1357.)