Vol.192 (2013.4.1) Impact Factor 2011 : 3.766  In 2013 (January to March), the average time for primary review for all original manuscripts submitted to Circulation Journal is 10.0 days. 3月6日にCirculation Journal iPad版アプリが公開となりました。 検索機能の付いた利便性の高い内容となっておりますので、是非ご利用下さい。 また、過去10年分のCirculation Journalをご覧いただくことが可能です。 Circulation Journal Vol.77 No.4 目次 Circulation Journalの目次を掲載した JCS Newsletter目次号を配信しています。 オンラインジャーナルと合わせてご利用ください。

◆オンラインジャーナルはこちら◆

Message From the Editor-in-Chief

Rapid Publication and Announcement of the 2013 JCS Meeting Activities
Hiroaki Shimokawa

・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・833

Reviews

Current and Future Clinical Applications of Cardiac Positron Emission Tomography
Hiroshi Ohira, Brian Mc Ardle, Myra S. Cocker, Robert A. deKemp, Jean N. DaSilva, Rob S. Beanlands

・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・836

Endothelial Loss and Repair in the Vascular Complications of Diabetes – Pathogenetic Mechanisms and Therapeutic Implications –
Richard E. Gilbert

・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・849

Renal Sympathetic Denervation for Treating Resistant Hypertension
Alberto Polimeni, Antonio Curcio, Ciro Indolfi

・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・857

Recent Mortality and Morbidity Rates of Japanese Atrial Fibrillation Patients – Racial Differences and Risk Stratification –
Takeshi Yamashita

・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・864

Invasive Imaging of Vulnerable Atherosclerotic Plaques in Coronary Artery Disease
Shiro Uemura

・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・869

Human Genomics in Cardiovascular Medicine – Implications and Perspectives –
Hiroyuki Morita

・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・876

Left Ventricular Stiffening as Therapeutic Target for Heart Failure With Preserved Ejection Fraction
Yasushi Sakata, Tomohito Ohtani, Yasuharu Takeda, Kazuhiro Yamamoto, Toshiaki Mano

・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・886

Editorials

Acute Rate Control in Atrial Fibrillation With Left Ventricular Dysfunction
Shin-ichi Momomura

・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・893

Statin Therapy in Chronic Heart Failure – Frog Prince or Bare Frog? –
Yasuki Kihara

・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・895

Targeting Transforming Growth Factor-β Signaling in Aortopathies in Marfan Syndrome
Daigo Sawaki, Toru Suzuki

・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・898

Is a Novel SCN3B Mutation Commonly Found in SCN5A-Negative Brugada Syndrome Patients?
Kazuya Kurakami, Kuniaki Ishii

・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・900

Titration of β-Blockers for Patients With Heart Failure
Toshihisa Anzai

・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・902

Measurement of Heart-Type Fatty Acid-Binding Protein Before Discharge
Takeshi Yamamoto, Masahiro Yasutake

・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・904

Prostacyclin – A Potential New Target for Endothelial Progenitor Cell-Mediated Angiogenesis –
Yuji Shiba, Uichi Ikeda

・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・906

Late Breaking Clinical Trials (JCS 2013)

Urgent Management of Rapid Heart Rate in Patients With Atrial Fibrillation/Flutter and Left Ventricular Dysfunction – Comparison of the Ultra-Short-Acting β1-Selective Blocker Landiolol With Digoxin (J-Land Study) –
Ryozo Nagai, Koichiro Kinugawa, Hiroshi Inoue, Hirotsugu Atarashi, Yoshihiko Seino, Takeshi Yamashita, Wataru Shimizu, Takeshi Aiba, Masafumi Kitakaze, Atsuhiro Sakamoto, Takanori Ikeda, Yasushi Imai, Takashi Daimon, Katsuhiro Fujino, Tetsuji Nagano, Tatsuaki Okamura, Masatsugu Hori, the J-Land Investigators

・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・908

Effects of Pitavastatin in Japanese Patients With Chronic Heart Failure – The Pitavastatin Heart Failure Study (PEARL Study) –
Hiroyuki Takano, Hiroshi Mizuma, Yoichi Kuwabara, Yasunori Sato, Satoshi Shindo, Norihiko Kotooka, Daisuke Fujimatsu, Yoshio Kobayashi, Teruo Inoue, Koichi Node, Issei Komuro on behalf of the PEARL Study Investigators

・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・917

Home-Based Disease Management Program to Improve Psychological Status in Patients With Heart Failure in Japan
Miyuki Tsuchihashi-Makaya, Hisashi Matsuo, Shigeo Kakinoki, Shigeru Takechi, Shintaro Kinugawa, Hiroyuki Tsutsui for the J-HOMECARE Investigators

・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・926

Late Breaking Cohort Studies (JCS 2013)

Management and Two-Year Long-Term Clinical Outcome of Acute Coronary Syndrome in Japan – Prevention of AtherothrombotiC Incidents Following Ischemic Coronary Attack (PACIFIC) Registry –
Hiroyuki Daida, Katsumi Miyauchi, Hisao Ogawa, Hiroyoshi Yokoi, Masayasu Matsumoto, Masafumi Kitakaze, Takeshi Kimura, Tetsuo Matsubara, Yuji Ikari, Kazuo Kimura, Kengo Tsukahara, Hideki Origasa, Yoshihiro Morino, Hiroyuki Tsutsui, Masayuki Kobayashi, Takaaki Isshiki on behalf of the PACIFIC investigators

・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・934

Clinical Features and Outcome in Hospitalized Heart Failure in Japan (From the ATTEND Registry)
Naoki Sato, Katsuya Kajimoto, Takehiko Keida, Masayuki Mizuno, Yuichiro Minami, Dai Yumino, Kuniya Asai, Koji Murai, Ryo Munakata, Toshiyuki Aokage, Yasushi Sakata, Kyoichi Mizuno, Teruo Takano

・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・944

Original Articles

Aortic Disease

Positive Correlation Between the Dysregulation of Transforming Growth Factor-β1 and Aneurysmal Pathological Changes in Patients With Marfan Syndrome
Koung Li Kim, Jeong Hoon Yang, Sun-Hwa Song, Ji Yeon Kim, Shin Yi Jang, Jeong-Min Kim, Jee-Ah Kim, Ki-Ick Sung, Young-Wook Kim, Yeon-Lim Suh, Wonhee Suh, Duk-Kyung Kim

・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・952

Arrhythmia/Electrophysiology

Novel SCN3B Mutation Associated With Brugada Syndrome Affects Intracellular Trafficking and Function of Nav1.5
Taisuke Ishikawa, Naohiko Takahashi, Seiko Ohno, Harumizu Sakurada, Kazufumi Nakamura, Young Keun On, Jeong Euy Park, Takeru Makiyama, Minoru Horie, Takuro Arimura, Naomasa Makita, Akinori Kimura

・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・959

Positive QRS Complex in Lead I as a Malignant Sign in Right Ventricular Outflow Tract Tachycardia – Comparison Between Polymorphic and Monomorphic Ventricular Tachycardia –
Kenji Kurosaki, Akihiko Nogami, Yasuhiro Shirai, Shinya Kowase

・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・968

Incidence and Predictors of Pericardial Effusion After Permanent Heart Rhythm Device Implantation – Prospective Evaluation of 968 Consecutive Patients –
Marc-Alexander Ohlow, Bernward Lauer, Michele Brunelli, J. Christoph Geller

・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・975

Cardiovascular Intervention

Kidney Enhancement on X-Rays Following Emergency Percutaneous Coronary Procedure Predicts Poor Short- and Long-Term Clinical Outcomes
Hiromichi Ueda, Takahisa Yamada, Masaharu Masuda, Takashi Morita, Yoshio Furukawa, Koji Tanaka, Yusuke Iwasaki, Takeshi Okada, Masato Kawasaki, Yuki Kuramoto, Takashi Naito, Tadao Fujimoto, Issei Komuro, Masatake Fukunami

・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・982

Incidence and Predictors for Late Target Lesion Revascularization After Sirolimus-Eluting Stent Implantation
Hironori Hara, Jiro Aoki, Kengo Tanabe, Shuzou Tanimoto, Yoshifumi Nakajima, Kazuyuki Yahagi, Makoto Nakashima, Takuya Hashimoto, Masahiko Asami, Mika Watanabe, Eri Yoshida, Hiroyoshi Nakajima, Kazuhiro Hara

・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・988

Cardiovascular Surgery

Change of Coronary Flow by Continuous-Flow Left Ventricular Assist Device With Cardiac Beat Synchronizing System (Native Heart Load Control System) in Acute Ischemic Heart Failure Model
Akihide Umeki, Takashi Nishimura, Masahiko Ando, Yoshiaki Takewa, Kenji Yamazaki, Shunei Kyo, Minoru Ono, Tomonori Tsukiya, Toshihide Mizuno, Yoshiyuki Taenaka, Eisuke Tatsumi

・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・995

Heart Failure

Trend of Clinical Outcome and Surrogate Markers During Titration of β-Blocker in Heart Failure Patients With Reduced Ejection Fraction – Relevance of Achieved Heart Rate and β-Blocker Dose –
Naoko Kato, Koichiro Kinugawa, Teruhiko Imamura, Hironori Muraoka, Shun Minatsuki, Toshiro Inaba, Hisataka Maki, Taro Shiga, Masaru Hatano, Atsushi Yao, Issei Komuro, Ryozo Nagai

・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・1001

Imaging

Comparison of Myocardial Perfusion Imaging Between the New High-Speed Gamma Camera and the Standard Anger Camera
Hirokazu Tanaka, Taishiro Chikamori, Satoshi Hida, Kenji Uchida, Yuko Igarashi, Tsuyoshi Yokoyama, Masaki Takahashi, Chie Shiba, Mana Yoshimura, Koichi Tokuuye, Akira Yamashina

・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・1009

Ischemic Heart Disease

Simultaneous Heart Rate Variability Monitoring Enhances the Predictive Value of Flow-Mediated Dilation in Ischemic Heart Disease
Shogo Watanabe, Eisuke Amiya, Masafumi Watanabe, Munenori Takata, Atsuko Ozeki, Aya Watanabe, Shuichi Kawarasaki, Tomoko Nakao, Yumiko Hosoya, Kazuko Omori, Koji Maemura, Issei Komuro, Ryozo Nagai

・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・1018

Elevated Serum Heart-Type Fatty Acid-Binding Protein in the Convalescent Stage Predicts Long-Term Outcome in Patients Surviving Acute Myocardial Infarction
Sen Matsumoto, Daisaku Nakatani, Yasuhiko Sakata, Shinichiro Suna, Masahiko Shimizu, Masaya Usami, Masahiko Hara, Satoru Sumitsuji, Shinsuke Nanto, Tatsuya Sasaki, Toshimitsu Hamasaki, Hiroshi Sato, Masatsugu Hori, Issei Komuro on Behalf of the Osaka Acute Coronary Insufficiency Study (OACIS) Group

・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・1026

Myocardial Disease

Exercise-Induced ST Elevation in Patients With Non-Ischemic Dilated Cardiomyopathy and Narrow QRS Complexes – Novel Predictor of Long-Term Prognosis From Exercise Testing –
Hiroyuki Takahama, Hiroshi Takaki, Yusuke Sata, Kazushi Sakane, Yasushi Ino, Teruo Noguchi, Yoichi Goto, Masaru Sugimachi

・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・1033

Impact of Septal Curvature on Regional Strain in Patients With Hypertrophic Cardiomyopathy
Katsuji Inoue, Hideki Okayama, Kazuhisa Nishimura, Takayuki Nagai, Jun Suzuki, Akiyoshi Ogimoto, Makoto Saito, Toyofumi Yoshii, Go Hiasa, Takumi Sumimoto, Jun-ichi Funada, Yuji Shigematsu, Mareomi Hamada, Jitsuo Higaki

・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・1040

Peripheral Vascular Disease

Comparison of Antiplatelet and Antithrombotic Therapy for Secondary Prevention of Ischemic Stroke in Patients With Peripheral Artery Disease – Population-Based Follow-up Study in Taiwan –
Wen-Hsien Lee, Chun-Yuan Chu, Po-Chao Hsu, Ho-Ming Su, Tsung-Hsien Lin, Wen-Chol Voon, Wen-Ter Lai, Sheng-Hsiung Sheu

・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・1046

Regenerative Medicine

Prostacyclin Stimulated Integrin-Dependent Angiogenic Effects of Endothelial Progenitor Cells and Mediated Potent Circulation Recovery in Ischemic Hind Limb Model
Yoko Aburakawa, Jun-ichi Kawabe, Motoi Okada, Atsushi Yamauchi, Akira Asanome, Maki Kabara, Motoki Matsuki, Naofumi Takehara, Naoki Nakagawa, Shunsuke Okumura, Yoshinori Minami, Yusuke Mizukami, Koh-ichi Yuhki, Fumitaka Ushikubi, Naoyuki Hasebe

・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・1053

Myocardial Layer-Specific Effect of Myoblast Cell-Sheet Implantation Evaluated by Tissue Strain Imaging
Yasuhiro Shudo, Shigeru Miyagawa, Satoshi Nakatani, Satsuki Fukushima, Taichi Sakaguchi, Atsuhiro Saito, Toshihiko Asanuma, Naomasa Kawaguchi, Nariaki Matsuura, Tatsuya Shimizu, Teruo Okano, Yoshiki Sawa

・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・1063

Vascular Biology and Vascular Medicine

Flow-Mediated Vasodilation and Anatomical Variation of the Brachial Artery (Double Brachial Artery) in Healthy Subjects and Patients With Cardiovascular Disease
Yuichi Fujii, Hiroki Teragawa, Junko Soga, Naomi Idei, Noritaka Fujimura, Tatsuya Maruhashi, Shinsuke Mikami, Yumiko Iwamoto, Takayuki Hidaka, Yasuki Kihara, Kazuaki Chayama, Kensuke Noma, Ayumu Nakashima, Chikara Goto, Yukihito Higashi

・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・1073

Images in Cardiovascular Medicine

Optical Coherence Tomography Is Superior to Intravascular Ultrasound for Diagnosis of Distal-Type Chronic Thromboembolic Pulmonary Hypertension
Shunsuke Tatebe, Yoshihiro Fukumoto, Koichiro Sugimura, Yutaka Miura, Kotaro Nochioka, Tatsuo Aoki, Masanobu Miura, Saori Yamamoto, Nobuhiro Yaoita, Kimio Satoh, Hiroaki Shimokawa

・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・1081

Letters to the Editor

Independent and Complementary Utility of Ambulatory Electrocardiogram-Based T-Wave Alternans and Heart Rate Turbulence for Predicting Major Cardiac Events in Patients After Myocardial Infarction
(Letter) Richard L. Verrier, Georg Schmidt

・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・1084

(Reply) Kyoko Hoshida, Yosuke Miwa, Mutsumi Miyakoshi, Takehiro Tsukada, Satoru Yusu, Hideaki Yoshino, Takanori Ikeda

・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・1086

■月刊誌 Circulation Journal Vol.77 No.4 広告掲載企業様一覧
クリアクター、コアテック、タンボコール、ニトロール、ワソラン（エーザイ株式会社）
サムスカ（大塚製薬株式会社）
グラクティブ（小野薬品工業株式会社）
プロサイリン、リピディル（科研製薬株式会社）
セイブル（株式会社 三和化学研究所）
オルメテック（第一三共株式会社）
ルプラック（大正富山医薬品株式会社）
アジルバ（武田薬品工業株式会社）
メインテート（田辺三菱製薬株式会社）
オートセットS（帝人ファーマ株式会社）
エポプロステノール（テバ製薬株式会社）
アテレック（持田製薬株式会社）
イグザレルト（バイエル薬品株式会社）
カルデナリン（ファイザー株式会社）
セララ（ファイザー株式会社）
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（順不同）

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