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Reviews

Clinical Research and the Development of Medical Therapeutics
Elliott M. Antman

・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・1267

Fibrosis, Electrics and Genetics – Perspectives on Sinoatrial Node Disease –
Gwilym M Morris, Jonathan M Kalman

・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・1272

Insights Into the Activation and Inhibition of Angiotensin II Type 1 Receptor in the Mechanically Loaded Heart
Jian Wu, Jieyun You, Shijun Wang, Li Zhang, Hui Gong, Yunzeng Zou

・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・1283

Three-Dimensional Speckle Tracking Echocardiography – A Promising Tool for Cardiac Functional Analysis –
Yoshihiro Seo, Tomoko Ishizu, Akiko Atsumi, Ryo Kawamura, Kazutaka Aonuma

・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・1290

Positron Emission Tomography-Computed Tomography for Imaging of Inflammatory Cardiovascular Diseases – Sarcoidosis, Large-Vessel Arteritis, and Atherosclerosis –
Masao Miyagawa, Rami Yokoyama, Yoshiko Nishiyama, Akiyoshi Ogimoto, Jitsuo Higaki, Teruhito Mochizuki

・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・1302

2014 ACC Report

Report of the American College of Cardiology (ACC) Scientific Sessions 2014, Washington, DC
Kenya Kusunose

・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・1311

Editorials

New Era of Oral Anticoagulation for Japanese Non-Valvular Atrial Fibrillation Patients
Teruyuki Hirano

・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・1317

Warfarin Therapy Still Survives as an Anticoagulation Treatment for Patients With Atrial Fibrillation – Importance of Maintaining the Target PT-INR –
Yuichiro Kawamura

・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・1320

Respiratory Resynchronization – A Novel Therapeutic Strategy –
Shin-ichi Ando

・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・1323

Can Coronary Angioscopy Predict Drug-Eluting Stent Thrombosis?
Takashi Kubo, Takashi Akasaka

・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・1325

Utilization of Oxidative Stress Biomarkers Is Important to Assess Treatment Effects on Exercise Capacity in Patients With Intermittent Claudication
Naoki Unno

・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・1327

Acute Kidney Injury and Acute Myocardial Infarction – Importance of Admission Hyperglycemia –
Toshiaki Ebina, Masami Kosuge, Kazuo Kimura

・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・1329

Which Score Should Be Used for Risk Stratification of Ischemic Stroke in Patients With Atrial Fibrillation – A Simple or Detailed Approach? –
Takanori Ikeda

・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・1331

Subclinical Hypothyroidism as a New Therapeutic Target for Patients With Heart Failure With Preserved Ejection Fraction
Yoshiharu Kinugasa, Kazuhiro Yamamoto

・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・1333

Original Articles

Arrhythmia/Electrophysiology

Intracranial Hemorrhage During Dabigatran Treatment – Case Series of Eight Patients –
Motohiro Komori, Masahiro Yasaka, Kazuhito Kokuba, Hideki Matsuoka, Shigeru Fujimoto, Megumu Yoshida, Katsuharu Kameda, Tadahisa Shono, Shinji Nagata, Tetsuro Ago, Takanari Kitazono, Yasushi Okada

・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・1335

Introduction of Point-of-Care Testing in Japanese Outpatient Clinics Is Associated With Improvement in Time in Therapeutic Range in Anticoagulant-Treated Patients
Yuji Okuyama, Miyuki Matsuo, Hiroshi Matsuo, Yoshihide Sakaguchi, Hiroyuki Takai, Yasunori Horiguchi, Teruhiko Ryomoto, Seiji Adachi, Toshio Amano, Masaki Togawa, Masaharu Masuda, Hitoshi Minamiguchi, Shinsuke Nanto, Issei Komuro, Yasushi Sakata

・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・1342

Rivaroxaban vs. Warfarin in Japanese Patients With Non-Valvular Atrial Fibrillation in Relation to Age – Insight From J-ROCKET AF –
Masatsugu Hori, Masayasu Matsumoto, Norio Tanahashi, Shin-ichi Momomura, Shinichiro Uchiyama, Shinya Goto, Tohru Izumi, Yukihiro Koretsune, Mariko Kajikawa, Masaharu Kato, Hitoshi Ueda, Kazuma Iekushi, Satoshi Yamanaka, Masahiro Tajiri on behalf of the J-ROCKET AF Study Investigators

・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・1349

Cardiovascular Intervention

Thirty-Day Outcome of Transcatheter Aortic Valve Implantation With the Edwards SAPIEN XT Prosthesis via the Transiliofemoral Approach – Japanese Single-Center Experience –
Yasushi Fuku, Tsuyoshi Goto, Tatsuhiko Komiya, Genichi Sakaguchi, Takeshi Shimamoto, Takeshi Maruo, Daiji Hasegawa, Suguru Otsuru, Naoki Saito, Yusuke Hyodo, Go Ueno, Kazushige Kadota, Kazuaki Mitsudo

・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・1357

Cardiovascular Surgery

Impact of Concomitant Surgical Atrial Fibrillation Ablation in Patients Undergoing Aortic Valve Replacement
Jae Suk Yoo, Joon Bum Kim, Sun Kyun Ro, Yoonsuh Jung, Sung-Ho Jung, Suk Jung Choo, Jae Won Lee, Cheol Hyun Chung

・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・1364

Early Hemodynamic Performance of the Trifecta Bioprosthetic Valve in Patients With Aortic Valve Disease – Initial Single-Center Experience in Japan –
Masaki Maruyama, Masao Daimon, Takayuki Kawata, Takatoshi Kasai, Ryoko Ichikawa, Sakiko Miyazaki, Hirotoshi Ohmura, Taira Yamamoto, Atsushi Amano, Hiroyuki Daida

・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・1372

Epidemiology

Body Mass Index-Modified Relationship of Chronic Mental Stress With Resting Blood Pressure During 5 Years in Japanese Middle-Aged Male Workers
Hideaki Toyoshima, Rei Otsuka, Shuji Hashimoto, Koji Tamakoshi, Hiroshi Yatsuya

・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・1379

Heart Failure

Differing Effects of Adaptive Servoventilation and Continuous Positive Airway Pressure on Muscle Sympathetic Nerve Activity in Patients With Heart Failure
Ryuichi Ushijima, Shuji Joho, Takashi Akabane, Yoshitaka Oda, Hiroshi Inoue

・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・1387

Status 2 Patients Had Poor Prognosis Without Mechanical Circulatory Support – Indications for Device Implantation –
Teruhiko Imamura, Koichiro Kinugawa, Masaru Hatano, Takeo Fujino, Toshiro Inaba, Hisataka Maki, Osamu Kinoshita, Eisuke Amiya, Kan Nawata, Atsushi Yao, Shunei Kyo, Minoru Ono, Issei Komuro

・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・1396

Medetomidine Suppresses Cardiac and Gastric Sympathetic Nerve Activities but Selectively Activates Cardiac Vagus Nerve
Shuji Shimizu, Tsuyoshi Akiyama, Toru Kawada, Atsunori Kamiya, Michael James Turner, Hiromi Yamamoto, Toshiaki Shishido, Mikiyasu Shirai, Masaru Sugimachi

・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・1405

Hypertension and Circulatory Control

Pathophysiological Contribution of Vascular Function to Baroreflex Regulation in Hypertension
Hirofumi Tomiyama, Chisa Matsumoto, Kazutaka Kimura, Mari Odaira, Kazuki Shiina, Akira Yamashina

・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・1414

Ischemic Heart Disease

Cilostazol Eliminates Adverse Smoking Outcome in Patients With Drug-Eluting Stent Implantation – Analysis of Longer-Term Follow-up of the CILON-T Randomized Trial –
Hack-Lyoung Kim, Jung-Won Suh, Seung-Pyo Lee, Hyun-Jae Kang, Bon-Kwon Koo, Young-Seok Cho, Tae-Jin Youn, In-Ho Chae, Dong-Ju Choi, Seung-Woon Rha, Jang-Ho Bae, Taek-Geun Kwon, Jang-Whan Bae, Myeong-Chan Cho, Hyo-Soo Kim

・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・1420

Atherosclerotic Change at One Year After Implantation of Endeavor Zotarolimus-Eluting Stent vs. Everolimus-Eluting Stent
Yasuhiro Akazawa, Koshi Matsuo, Yasunori Ueda, Mayu Nishio, Akio Hirata, Mitsutoshi Asai, Takayoshi Nemoto, Mitsuru Wada, Ayaka Murakami, Kazunori Kashiwase, Kazuhisa Kodama

・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・1428

Myocardial Disease

Carbon Monoxide-Induced Cardiomyopathy – Epidemiology, Clinical Characteristics and Prognosis –
Yoon-seok Jung, Ji-sook Lee, Young-gi Min, Jin-sun Park, Woo-chan Jeon, Eun-jung Park, Joon-han Shin, Sungho Oh, Sang-Cheon Choi

・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・1437

Peripheral Vascular Disease

Impact of Endovascular Therapy on Oxidative Stress in Patients With Peripheral Artery Disease
Soichiro Ebisawa, Yuichiro Kashima, Yusuke Miyashita, Saeko Yamazaki, Naoyuki Abe, Tatsuya Saigusa, Takashi Miura, Hirohiko Motoki, Atsushi Izawa, Uichi Ikeda

・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・1445

Effect of Bare-Metal Nitinol Stent Implantation and Paclitaxel-Eluting Nitinol Stent Implantation on Vascular Response in the Superficial Femoral Artery Lesion Assessed on Intravascular Ultrasound
Kojiro Miki, Kenichi Fujii, Daizo Kawasaki, Masashi Fukunaga, Machiko Nishimura, Tetsuo Horimatsu, Ten Saita, Hiroto Tamaru, Takahiro Imanaka, Masahiko Shibuya, Motomaru Masutani, Mitsumasa Ohyanagi, Tohru Masuyama

・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・1451

Pulmonary Circulation

High-Altitude Hypoxia and Echocardiographic Indices of Pulmonary Hypertension in Male and Female Chickens at Adulthood
Carlos E. Salinas, Carlos E. Blanco, Mercedes Villena, Dino A. Giussani

・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・1459

Role of Endothelial Nitric Oxide Synthase and Collagen Metabolism in Right Ventricular Remodeling due to Pulmonary Hypertension
Suvd Nergui, Yoshihiro Fukumoto, Zhulanqiqige Do.e, Sota Nakajima, Toru Shimizu, Shohei Ikeda, Md. Elias-Al-Mamun, Hiroaki Shimokawa

・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・1465

Renal Disease

Admission Hyperglycemia Is an Independent Predictor of Acute Kidney Injury in Patients With Acute Myocardial Infarction
Noriaki Moriyama, Masaharu Ishihara, Teruo Noguchi, Michio Nakanishi, Tetsuo Arakawa, Yasuhide Asaumi, Leon Kumasaka, Tomoaki Kanaya, Tadayoshi Miyagi, Toshiyuki Nagai, Takafumi Yamane, Masashi Fujino, Satoshi Honda, Reiko Fujiwara, Toshihisa Anzai, Kengo Kusano, Yoichi Goto, Satoshi Yasuda, Hisao Ogawa

・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・1475

Stroke

CHADS₂, CHA₂DS₂-VASc, and R₂CHADS₂ Scores Are Associated With 3-Month Functional Outcome of Stroke in Patients With Prior Coronary Artery Disease
Takao Hoshino, Kentaro Ishizuka, Satoru Shimizu, Shinichiro Uchiyama

・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・1481

Valvular Heart Disease

A Novel Role of Sympathetic Activity in Regulating Mitral Valve Prolapse
Xiang Hu, Hao-Zhe Wang, Jun Liu, An-Qin Chen, Xiao-Feng Ye, Qiang Zhao

・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・1486

Vascular Biology and Vascular Medicine

Elevated Arterial Stiffness and Diastolic Dysfunction in Subclinical Hypothyroidism
Mitsuru Masaki, Kazuo Komamura, Akiko Goda, Shinichi Hirotani, Misato Otsuka, Ayumi Nakabo, Miho Fukui, Shohei Fujiwara, Masataka Sugahara, Masaaki Lee-Kawabata, Takeshi Tsujino, Masahiro Koshiba, Tohru Masuyama

・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・1494

Capacity and Hypoxic Response of Subcutaneous Adipose Tissue Blood Flow in Humans
Ilkka Heinonen, Jukka Kemppainen, Kimmo Kaskinoro, Juhani Knuuti, Robert Boushel, Kari K. Kalliokoski

・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・1501

Images in Cardiovascular Medicine

Cardiac Magnetic Resonance Imaging of Left Ventricular Apical Hypoplasia in Two Complex Congenital Clinical Syndromes
Matteo Baroni, Patrizia Pedrotti, Stefano Nava, Cristina Giannattasio, Alberto Roghi

・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・1507

Cardiac Tamponade – Complication of Inferior Vena Cava Filter Retrieval –
Jackson J. Liang, Sunil V. Mankad, C. Michael Johnson, Leslie T. Cooper

・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・1510

■月刊誌 Circulation Journal Vol.78 No.6 広告掲載企業様一覧
フォシーガ（アストラゼネカ株式会社）
クリアクター、コアテック、タンボコール、ニトロール、ワソラン（エーザイ株式会社）
サムスカ（大塚製薬株式会社）
プロサイリン（科研製薬株式会社）
スイニー、リバロ（興和創薬株式会社）
ダイアート（株式会社三和化学研究所）
エフィエント（第一三共株式会社）
オルメテック（第一三共株式会社）
アジルバ、ザクラス（武田薬品工業株式会社）
ビソノテープ（トーアエイヨー株式会社）
ラジレス（ノバルティスファーマ株式会社）
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ＶaSera、FM-190（フクダ電子株式会社）
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