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Message From the Editor-in-Chief

Message From the Editor-in-Chief
Hiroaki Shimokawa

・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・1513

Reviews

Troponin I-Interacting Protein Kinase – A Novel Cardiac-Specific Kinase, Emerging as a Molecular Target for the Treatment of Cardiac Disease –
Hind Lal, Firdos Ahmad, Shan Parikh, Thomas Force

・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・1514

Roles of Xenobiotic Receptors in Vascular Pathophysiology
Lei Xiao, Zihui Zhang, Xiaoqin Luo

・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・1520

Assessment of Plaque Composition by Intravascular Ultrasound and Near-Infrared Spectroscopy – From PROSPECT I to PROSPECT II –
Salvatore Brugaletta, Manel Sabaté

・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・1531

Contemporary Infrapopliteal Intervention for Limb Salvage and Wound Healing – Harmonization of Revascularization and Wound Management –
Osami Kawarada, Satoshi Yasuda, Janice Huang, Yasuhiro Honda, Peter J. Fitzgerald, Masaharu Ishihara, Hisao Ogawa

・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・1540

Focus Issue on Takotsubo Cardiomyopathy

Pathophysiology of Takotsubo Syndrome – Temporal Phases of Cardiovascular Responses to Extreme Stress –
Peter T. Wright, Matthew H. Tranter, Andrew C. Morley-Smith, Alexander R. Lyon

・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・1550

Clinical Management of Takotsubo Cardiomyopathy
Satoshi Kurisu, Yasuki Kihara

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Editorials

How Should We Apply the CHA₂DS₂-VASc Score to Non-Valvular Atrial Fibrillation Patients in Japan?
Masahiro Yasaka

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Exercise-Based Cardiac Rehabilitation Is Safe, Yet Underused in Japan
Atsushi Katoh, Hisao Ikeda

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Preoperative Fibrinogen and Morbidity in Patients With Residual Platelet Inhibition Undergoing Off- Pump Coronary Artery Bypass Grafting – Cause or Effect? –
Davide Capodanno

・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・1571

Intravascular Molecular Imaging for Atherosclerosis – A Fledgling but Realistic World With Lights and Ultrasounds –
Takafumi Hiro

・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・1574

Impact of the Adjusted Dosing Regimen of Prasugrel for Japanese Patients With Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention
Jun Takahashi

・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・1577

Current Status and Future Direction of Cardiac Resynchronization Therapy for Congenital Heart Disease and Pediatric Patients
Hitoshi Horigome

・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・1579

Stem Cells Bond Our Organs/Tissues and Engineering Products
Masashi Toyoda, Akihiro Umezawa

・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・1582

Original Articles

Arrhythmia/Electrophysiology

Effect of Left Atrial Activity After the Maze Procedure on Clinical and Echocardiographic Outcomes
Seung-Jung Park, Young Keun On, June Soo Kim, Dong Seop Jeong, Wook Sung Kim, Kiick Sung, Young Tak Lee, Pyo Won Park

・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・1584

Validation of CHA₂DS₂-VASc and HAS-BLED Scores in Japanese Patients With Nonvalvular Atrial Fibrillation – An Analysis of the J-RHYTHM Registry –
Ken Okumura, Hiroshi Inoue, Hirotsugu Atarashi, Takeshi Yamashita, Hirofumi Tomita, Hideki Origasa for the J-RHYTHM Registry Investigators

・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・1593

Hyperuricemia and Transesophageal Echocardiographic Thromboembolic Risk in Patients With Atrial Fibrillation at Clinically Low-Intermediate Risk
Satoshi Numa, Tadakazu Hirai, Keiko Nakagawa, Kazumasa Ohara, Nobuyuki Fukuda, Takashi Nozawa, Hiroshi Inoue

・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・1600

Upper Limit of Vulnerability During Defibrillator Implantations Predicts the Occurrence of Appropriate Shock Therapy for Ventricular Fibrillation
Soichiro Yamashita, Akihiro Yoshida, Koji Fukuzawa, Ryudo Fujiwara, Atsushi Suzuki, Tomoyuki Nakanishi, Akinori Matsumoto, Hiroki Konishi, Hirotoshi Ichibori, Ken-ichi Hirata

・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・1606

Learning Curve in Cryoballoon Ablation of Atrial Fibrillation – Eight-Year Experience –
Maciej Wójcik, Alexander Berkowitsch, Harald Greis, Sergey Zaltsberg, Christian W. Hamm, Heinz F. Pitschner, Malte Kuniss, Thomas Neumann

・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・1612

Tissue Velocity Imaging-Based Atrial Fibrillatory Cycle Length and Wall Motion for Predicting Atrial Structural Remodeling in Patients Undergoing Catheter Ablation
Kazumasa Sonoda, Yasuo Okumura, Ichiro Watanabe, Koichi Nagashima, Masayoshi Kofune, Hiroaki Mano, Rikitake Kogawa, Naoko Sasaki, Kimie Ohkubo, Toshiko Nakai, Atsushi Hirayama

・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・1619

Cardiovascular Intervention

Long-Term Efficacy and Safety Outcomes After Unrestricted Use of Drug-Eluting Stents in Patients With Acute Coronary Syndrome – Mortality and Major Bleeding in a Single-Center Registry –
Tetsuma Kawaji, Hiroki Shiomi, Takeshi Morimoto, Toshihiro Tamura, Ryusuke Nishikawa, Mariko Yano, Junichi Tazaki, Masao Imai, Naritatsu Saito, Takeru Makiyama, Satoshi Shizuta, Koh Ono, Takeshi Kimura

・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・1628

Cardiac Rehabilitation

Exercise Preconditioning-Induced Early and Late Phase of Cardioprotection Is Associated With Protein Kinase C Epsilon Translocation
Zhe Hao, Shan-Shan Pan, Yu-Jun Shen, Jun Ge

・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・1636

Safety of Exercise-Based Cardiac Rehabilitation and Exercise Testing for Cardiac Patients in Japan – A Nationwide Survey –
Masahiko Saito, Kenji Ueshima, Muneyasu Saito, Toshiji Iwasaka, Hiroyuki Daida, Masahiro Kohzuki, Shigeru Makita, Hitoshi Adachi, Hiroyoshi Yokoi, Kazuto Omiya, Hiroshi Mikouchi, Hiroyuki Yokoyama, Yoichi Goto for the Japanese Cardiac Rehabilitation Survey Investigators

・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・1646

Cardiovascular Surgery

Fate of Atrioventricular Valve Function of the Transplanted Heart
Gwan Sic Kim, Jae-Joong Kim, Joon Bum Kim, Dae-Hee Kim, Jong-Min Song, Tae-Jin Yun, Suk Jung Choo, Duk-Hyun Kang, Cheol Hyun Chung, Jae-Kwan Song, Jae Won Lee, Sung-Ho Jung

・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・1654

Impact of Preoperative Fibrinogen Concentration on Postoperative Outcome in Patients Who Received Dual Antiplatelet Therapy in Proximity to Off-Pump Coronary Bypass Surgery
Na Young Kim, Jae-Kwang Shim, Jong Wook Song, Eui-Kyung Kim, Young-Lan Kwak

・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・1661

Imaging

Imaging of Native High-Density Lipoprotein in Human Coronary Plaques by Color Fluorescent Angioscopy
Yasuto Uchida, Nobuyuki Hiruta, Daisuke Yamanoi, Ei Shimoyama, Yuko Maezawa, Yasumi Uchida

・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・1667

Usefulness of Stress Myocardial Perfusion Imaging and Baseline Clinical Factors for Predicting Cardiovascular Events in Patients With Prior Coronary Artery Disease
Tatsuhiko Furuhashi, Masao Moroi, Toru Awaya, Megumi Minakawa, Hirofumi Masai, Taeko Kunimasa, Hiroshi Fukuda

・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・1676

Ischemic Heart Disease

Efficacy and Safety of Adjusted-Dose Prasugrel Compared With Clopidogrel in Japanese Patients With Acute Coronary Syndrome – The PRASFIT-ACS Study –
Shigeru Saito, Takaaki Isshiki, Takeshi Kimura, Hisao Ogawa, Hiroyoshi Yokoi, Shinsuke Nanto, Morimasa Takayama, Kazuo Kitagawa, Masakatsu Nishikawa, Shunichi Miyazaki, Masato Nakamura

・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・1684

Myocardial Disease

Stiffness of Left Ventricular Cardiac Fibroblasts Is Associated With Ventricular Dilation in Patients With Recent-Onset Nonischemic and Nonvalvular Cardiomyopathy
Michael Glaubitz, Stephan Block, Jeannine Witte, Klaus Empen, Stefan Gross, Robert Schlicht, Kerstin Weitmann, Karin Klingel, Reinhard Kandolf, Wolfgang Hoffmann, Kay E. Gottschalk, Mathias Busch, Marcus Dörr, Christiane A. Helm, Stephan B. Felix, Alexander Riad

・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・1693

Pediatric Cardiology and Adult Congenital Heart Disease

Left Atrial Volume Is Superior to the Ratio of the Left Atrium to Aorta Diameter for Assessment of the Severity of Patent Ductus Arteriosus in Extremely Low Birth Weight Infants
Katsuaki Toyoshima, Satoshi Masutani, Hideaki Senzaki, Motoyoshi Kawataki, Yasushi Itani

・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・1701

Current Trends in Use of Implantable Cardioverter Defibrillators and Cardiac Resynchronization Therapy With a Pacemaker or Defibrillator in Japanese Pediatric Patients – Results From a Nationwide Questionnaire Survey –
Tsugutoshi Suzuki, Naokata Sumitomo, Jun Yoshimoto, Aya Miyazaki, Kazuhiro Hinokiyama, Hiroya Ushinohama, Satoshi Yasukochi

・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・1710

Ventricular Sympathetic Innervation in Patients With Transposition of the Great Arteries After Arterial Switch Operation and Rastelli Procedure – Impact of Arterial Dissection and Coronary Reimplantation –
Andreas Kuehn, Manfred Vogt, Markus Schwaiger, Peter Ewert, Michael Hauser

・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・1717

Peripheral Vascular Disease

Utility of Noninvasive Endothelial Function Test for Prediction of Deep Vein Thrombosis After Total Hip or Knee Arthroplasty
Hiroyuki Suzuki, Yasushi Matsuzawa, Masaaki Konishi, Eiichi Akiyama, Keiko Takano, Naoki Nakayama, Shunsuke Kataoka, Toshiaki Ebina, Masami Kosuge, Kiyoshi Hibi, Kengo Tsukahara, Noriaki Iwahashi, Mitsuaki Endo, Nobuhiko Maejima, Kentaro Shinohara, Naoya Taki, Naoto Mitsugi, Masataka Taguri, Seigo Sugiyama, Hisao Ogawa, Satoshi Umemura, Kazuo Kimura

・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・1723

A Study of Leg Edema in Immobile Patients
Kotaro Suehiro, Noriyasu Morikage, Masanori Murakami, Osamu Yamashita, Koshiro Ueda, Makoto Samura, Kimikazu Hamano

・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・1733

Borderline Ankle-Brachial Index Value of 0.91–0.99 Is Associated With Endothelial Dysfunction
Masato Kajikawa, Tatsuya Maruhashi, Yumiko Iwamoto, Akimichi Iwamoto, Takeshi Matsumoto, Takayuki Hidaka, Yasuki Kihara, Kazuaki Chayama, Ayumu Nakashima, Chikara Goto, Kensuke Noma, Yukihito Higashi

・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・1740

Wound Healing and Wound Location in Critical Limb Ischemia Following Endovascular Treatment
Norihiro Kobayashi, Keisuke Hirano, Masatsugu Nakano, Toshiya Muramatsu, Reiko Tsukahara, Yoshiaki Ito, Hiroshi Ishimori

・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・1746

Pulmonary Circulation

Association of Plasma Fibrinogen and Plasminogen With Prognosis of Inoperable Chronic Thromboembolic Pulmonary Hypertension
Fumiaki Kato, Nobuhiro Tanabe, Takashi Urushibara, Hajime Kasai, Takao Takeuchi, Ayumi Sekine, Rika Suda, Rintaro Nishimura, Takayuki Jujo, Toshihiko Sugiura, Ayako Shigeta, Seiichiro Sakao, Yasunori Kasahara, Koichiro Tatsumi

・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・1754

Regenerative Medicine

Adipose-Derived Stem Cells Stimulate Reendothelialization in Stented Rat Abdominal Aorta
Tomohiko Sato, Masao Takahashi, Daishi Fujita, Shigeyoshi Oba, Hiroaki Nishimatsu, Tetsuo Nagano, Etsu Suzuki

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Images in Cardiovascular Medicine

Abnormal Hemodynamics in the Pulmonary Artery Seen on Time-Resolved 3-Dimensional Phase- Contrast Magnetic Resonance Imaging (4D-Flow) in a Young Patient With Idiopathic Pulmonary Arterial Hypertension
Keiichi Odagiri, Naoki Inui, Sachiko Miyakawa, Akio Hakamata, Jiazhang Wei, Yasuo Takehara, Harumi Sakahara, Masataka Sugiyama, Marcus T. Alley, Quang-Kim Tran, Hiroshi Watanabe

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Corrigendum

・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・1773

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■月刊誌 Circulation Journal Vol.78 No.7 広告掲載企業様一覧
フォシーガ（アストラゼネカ株式会社）
クリアクター、コアテック、タンボコール、ニトロール、ワソラン（エーザイ株式会社）
サムスカ（大塚製薬株式会社）
リピディル（科研製薬株式会社）
グルベス（キッセイ薬品工業株式会社）
リバロ、スイニー（興和創薬株式会社）
スイニー、セイブル（株式会社 三和化学研究所）
エフィエント（第一三共株式会社）
レザルタス（第一三共株式会社）
ルプラック（大正富山医薬品株式会社）
アイミクス（大日本住友製薬株式会社）
アジルバ、ザクラス（武田薬品工業株式会社）
メインテート（田辺三菱製薬株式会社）
ミカルディス　他（日本ベーリンガーインゲルハイム(株)）
ラジレス（ノバルティスファーマ株式会社）
ドクターソフト（株式会社油井コンサルティング）
VaSera、ＦＭ１９０（フクダ電子株式会社）
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