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Message From the Editor-in-Chief

Circulation Journal Awards for the Year 2017
Toyoaki Murohara

Reviews

High-Frequency Echocardiography - Transformative Clinical and Research Applications in Humans, Mice, and Zebrafish -
Louis W. Wang, Scott H. Kesteven, Inken G. Huttner, Michael P. Feneley, Diane Fatkin

Inflammatory Mechanisms of Cardiovascular Remodeling
Toshihisa Anzai

Rapid Globalization of Medical Device Clinical Development Programs in Japan - The Case of Drug- Eluting Stents -
Madoka Murakami, Yuka Suzuki, Toshiyoshi Tominaga

Editorials

Novel Therapeutic Target of Anticoagulation Therapy in Patients With Atrial Fibrillation - Cognitive Decline and Dementia -
Eitaro Kodani, Takehiko Nagao

Impact of Anemia on Left Ventricular Reverse Remodeling in Response to Carvedilol
Akiomi Yoshihisa

Left Ventricular Fiber Structure and Myocardial Deformation for Assessment of Cardiotoxicity
Ikuo Hashimoto, Fukiko Ichida

Risk of Cardiovascular Disease After Earthquake Disaster
Seiji Hokimoto

Original Articles

Arrhythmia/Electrophysiology

Outcomes of Rate-Control Treatment in Patients With Atrial Fibrillation and Heart Failure - A Nationwide Cohort Study -
Hee Tae Yu, Pil-Sung Yang, Hancheol Lee, Seng Chan You, Tae-Hoon Kim, Jae-Sun Uhm, Jong-Youn Kim, Hui-Nam Pak, Moon-Hyoung Lee, Boyoung Joung

Predictors of a Persistent Status of Pulmonary Vein Electrical Isolation by a Cryoballoon Application for Drug-Refractory Atrial Fibrillation
Naohiko Kawaguchi, Kaoru Okishige, Yasuteru Yamauchi, Manabu Kurabayashi, Kenzo Hirao

Does Size Matter? Cryoballoon-Based Pulmonary Vein Isolation Using a Novel 25-mm Circular Mapping Catheter
Bruno Reissmann, Michael Schlüter, Francesco Santoro, Tilman Maurer, Christian-Hendrik Heeger, Christine Lemes, Thomas Fink, Johannes Riedl, Andreas Rillig, Shibu Mathew, Feifan Ouyang, Karl-Heinz Kuck, Andreas Metzner

Silent Cerebral Infarction in East Asian vs. Non-Asian Atrial Fibrillation Patients - Meta-Analysis -
Keitaro Senoo, Yusuke Kondo, Yoshio Kobayashi, Gregory YH Lip

Cardiovascular Surgery

Association Between Platelet Count and Postoperative Blood Loss in Patients Undergoing Cardiac Surgery With Cardiopulmonary Bypass and Fresh Frozen Plasma Administration Guided by Thromboelastometry
Junko Ichikawa, Yoshiko Osada, Mitsuharu Kodaka, Keiko Nishiyama, Makiko Komori

Evidence of Pulmonary Vascular Reverse Remodeling After Pulmonary Artery Banding Performed in Early Infancy in Patients With Congenital Heart Defects
Naoki Masaki, Yuriko Saiki, Masato Endo, Kay Maeda, Osamu Adachi, Masatoshi Akiyama, Shunsuke Kawamoto, Yoshikatsu Saiki

Heart Failure

Anemia Is Associated With Blunted Response to β-Blocker Therapy Using Carvedilol - Insights From Japanese Chronic Heart Failure (J-CHF) Study -
Yuji Nagatomo, Tsutomu Yoshikawa, Hiroshi Okamoto, Akira Kitabatake, Masatsugu Hori on behalf of J-CHF Investigators

Early Prediction Model for Successful Bridge to Recovery in Patients With Fulminant Myocarditis Supported With Percutaneous Venoarterial Extracorporeal Membrane Oxygenation - Insights From the CHANGE PUMP Study -
Akinori Sawamura, Takahiro Okumura, Akihiro Hirakawa, Masaaki Ito, Yukio Ozaki, Nobuyuki Ohte, Tetsuya Amano, Toyoaki Murohara on behalf of the CHANGE PUMP Investigators

Association of Age at Menarche With Left Ventricular Diastolic Dysfunction in Middle-Aged Women
Seungho Ryu, Yoosoo Chang, Jeong Gyu Kang, Jidong Sung, Jang-Young Kim, Hyun-Suk Jung, Kyung Eun Yun, Chan-Won Kim, Juhee Cho, Min-Jung Kwon, Kye-Hyun Kim, Hocheol Shin, Ki-Chul Sung

In-Depth Insight Into the Mechanisms of Cardiac Dysfunction in Patients With Childhood Cancer After Anthracycline Treatment Using Layer-Specific Strain Analysis
Kana Yazaki, Ken Takahashi, Sachie Shigemitsu, Mariko Yamada, Takeshi Iso, Maki Kobayashi, Katsumi Akimoto, Hiroyuki Tamaichi, Junya Fujimura, Masahiro Saito, Masaki Nii, Toshiaki Shimizu

Applying the Seattle Heart Failure Model in the Office Setting in the Era of Electronic Medical Records
Brent A. Williams, Shikhar Agarwal

Left Ventricular Mass Influences Relationship Between Filling Pressure and Early-Diastolic Ratio of Inflow Velocity to Mitral Annular Velocity (E/e′)
Masahiro Nakabachi, Satoshi Yamada, Hiroyuki Iwano, Taichi Hayashi, Kazunori Okada, Kenya Kusunose, Kiyotaka Watanabe, Tomoko Ishizu, Kazuaki Wakami, Hirotsugu Yamada, Kaoru Dohi, Yoshihiro Seo, Nobuyuki Ohte, Chikara Shimizu, Taisei Mikami

Imaging

Increased Prognostic Value of Query Amyloid Late Enhancement Score in Light-Chain Cardiac Amyloidosis
Ke Wan, Jiayu Sun, Yuchi Han, Hong Liu, Dan Yang, Weihao Li, Jie Wang, Wei Cheng, Qing Zhang, Zhi Zeng, Yucheng Chen

Ischemic Heart Disease

Cardiovascular and Bleeding Risks in Acute Myocardial Infarction Newly Treated With Ticagrelor vs. Clopidogrel in Taiwan
Cheng-Han Lee, Ching-Lan Cheng, Yea-Huei Kao Yang, Ting-Hsing Chao, Ju-Yi Chen, Yi-Heng Li

Effects of Ezetimibe-Statin Combination Therapy on Coronary Atherosclerosis in Acute Coronary Syndrome
Kiyoshi Hibi, Shinjo Sonoda, Masanori Kawasaki, Yutaka Otsuji, Toyoaki Murohara, Hideki Ishii, Katsuhiko Sato, Ryoji Koshida, Yukio Ozaki, Masataka Sata, Yoshihiro Morino, Tadashi Miyamoto, Tetsuya Amano, Satoshi Morita, Ken Kozuma, Kazuo Kimura, Hisayoshi Fujiwara for the Ezetimibe-ACS Investigators

Changes in Serum Fibroblast Growth Factor 23 in Patients With Acute Myocardial Infarction
Hideaki Takahashi, Michishige Ozeki, Tomohiro Fujisaka, Hideaki Morita, Shu-ichi Fujita, Yoshihiro Takeda, Kensaku Shibata, Koichi Sohmiya, Masaaki Hoshiga, Junko Tamaki, Nobukazu Ishizaka

Diastolic Dysfunction Is a Risk of Perioperative Myocardial Injury Assessed by High-Sensitivity Cardiac Troponin T in Elderly Patients Undergoing Non-Cardiac Surgery
Hironobu Toda, Kazufumi Nakamura, Koji Nakagawa, Atsuyuki Watanabe, Toru Miyoshi, Nobuhiro Nishii, Kazuyoshi Shimizu, Masao Hayashi, Hiroshi Morita, Hiroshi Morimatsu, Hiroshi Ito

Diagnosis and Management of Spontaneously Recanalized Coronary Thrombus Guided by Optical Coherence Tomography - Lessons From the French “Lotus Root” Registry -
Géraud Souteyrand, Mathieu Valladier, Nicolas Amabile, François Derimay, Brahim Harbaoui, Pierre Leddet, Pierre Barnay, Guilhem Malcles, Aurelien Mulliez, Colin Berry, Romain Eschalier, Nicolas Combaret, Pascal Motreff

Predictive Validity of CRUSADE, ACTION and ACUITY-HORIZONS Bleeding Risk Scores in Chinese Patients With ST-Segment Elevation Myocardial Infarction
Ran Liu, Wen Zheng, Guanqi Zhao, Xiao Wang, Xuedong Zhao, Shenghui Zhou, Shaoping Nie

Two-Year Outcomes and Predictors of Target Lesion Revascularization for Non-Left Main Coronary Bifurcation Lesions Following Two-Stent Strategy With 2nd-Generation Drug-Eluting Stents
Masanobu Ohya, Takeshi Morimoto, Shunsuke Kubo, Seiji Habara, Akimune Kuwayama, Katsuya Miura, Takenobu Shimada, Hidewo Amano, Suguru Otsuru, Takeshi Tada, Hiroyuki Tanaka, Yasushi Fuku, Tsuyoshi Goto, Kazushige Kadota

Diagnostic Accuracy of Quantitative Flow Ratio for Assessing Myocardial Ischemia in Prior Myocardial Infarction
Hiroki Emori, Takashi Kubo, Takeyoshi Kameyama, Yasushi Ino, Yoshiki Matsuo, Hironori Kitabata, Kosei Terada, Yosuke Katayama, Hiroshi Aoki, Akira Taruya, Kunihiro Shimamura, Shingo Ota, Atsushi Tanaka, Takeshi Hozumi, Takashi Akasaka

Intravascular Ultrasound-Derived Virtual Fractional Flow Reserve for the Assessment of Myocardial Ischemia
Fumiyasu Seike, Teruyoshi Uetani, Kazuhisa Nishimura, Hiroshi Kawakami, Haruhiko Higashi, Akira Fujii, Jun Aono, Takayuki Nagai, Katsuji Inoue, Jun Suzuki, Shinji Inaba, Takafumi Okura, Kazunori Yasuda, Jitsuo Higaki, Shuntaro Ikeda

Myocardial Disease

Patients’ Characteristics and Clinical Course of Hypertrophic Cardiomyopathy in a Regional Japanese Cohort - Results From Kochi RYOMA Study -
Toru Kubo, Takayoshi Hirota, Yuichi Baba, Yuri Ochi, Asa Takahashi, Naohito Yamasaki, Naohisa Hamashige, Katsuhito Yamamoto, Fumiaki Kondo, Kanji Bando, Eisuke Yamada, Takashi Furuno, Toshikazu Yabe, Yoshinori L Doi, Hiroaki Kitaoka

Pediatric Cardiology and Adult Congenital Heart Disease

Standard Values and Characteristics of Electrocardiographic Findings in Children and Adolescents
Masao Yoshinaga, Mari Iwamoto, Hitoshi Horigome, Naokata Sumitomo, Hiroya Ushinohama, Naomi Izumida, Nobuo Tauchi, Tatsuya Yoneyama, Katsumi Abe, Masami Nagashima

Clinical Characteristics of Adult Patients With Congenital Heart Disease Hospitalized for Acute Heart Failure
Jun Negishi, Hideo Ohuchi, Aya Miyazaki, Etsuko Tsuda, Isao Shiraishi, Kenichi Kurosaki

Peripheral Vascular Disease

Impact of Objective Malnutrition Status on the Clinical Outcomes in Patients With Peripheral Artery Disease Following Endovascular Therapy
Miyuki Yokoyama, Tetsu Watanabe, Yoichiro Otaki, Ken Watanabe, Taku Toshima, Takayuki Sugai, Tetsuya Takahashi, Daisuke Kinoshita, Harutoshi Tamura, Satoshi Nishiyama, Hiroki Takahashi, Takanori Arimoto, Tetsuro Shishido, Sou Yamauchi, Tamon Yamanaka, Takuya Miyamoto, Isao Kubota

Renal Disease

Association Between Elevated Echocardiographic Index of Left Ventricular Filling Pressure and Acute Kidney Injury After Off-Pump Coronary Artery Surgery
Min Hur, Karam Nam, Woo Young Jo, Gahyun Kim, Won Ho Kim, Jae-Hyon Bahk

Stroke

Fibrin Clot Architecture in Acute Ischemic Stroke Treated With Mechanical Thrombectomy With Stent- Retrievers - Cohort Study -
Dagmar Krajíčková, Antonín Krajina, Ivo šteiner, Oldřich Vyšata, Roman Herzig, Miroslav Lojík, Vendelín Chovanec, Jan Raupach, Ondřej Renc, Jan Waishaupt, Eva Vítková, Petr Dulíček, Pavla čabelková, Martin Vališ

Valvular Heart Disease

Acute Heart Failure in Patients With Severe Aortic Stenosis - Insights From the CURRENT AS Registry -
Kazuya Nagao, Tomohiko Taniguchi, Takeshi Morimoto, Hiroki Shiomi, Kenji Ando, Norio Kanamori, Koichiro Murata, Takeshi Kitai, Yuichi Kawase, Chisato Izumi, Makoto Miyake, Hirokazu Mitsuoka, Masashi Kato, Yutaka Hirano, Shintaro Matsuda, Tsukasa Inada, Tomoyuki Murakami, Yasuyo Takeuchi, Keiichiro Yamane, Mamoru Toyofuku, Mitsuru Ishii, Eri Minamino-Muta, Takao Kato, Moriaki Inoko, Tomoyuki Ikeda, Akihiro Komasa, Katsuhisa Ishii, Kozo Hotta, Nobuya Higashitani, Yoshihiro Kato, Yasutaka Inuzuka, Chiyo Maeda, Toshikazu Jinnai, Yuko Morikami, Naritatsu Saito, Kenji Minatoya, Takeshi Kimura on behalf of the CURRENT AS Registry Investigators

Definitive Determinant of Late Significant Tricuspid Regurgitation After Aortic Valve Replacement
Shin Yajima, Daisuke Yoshioka, Koichi Toda, Satsuki Fukushima, Shigeru Miyagawa, Yasushi Yoshikawa, Shunsuke Saito, Keitaro Domae, Takayoshi Ueno, Toru Kuratani, Yoshiki Sawa

Transcatheter Aortic Valve Implantation (TAVI) for Native Aortic Valve Regurgitation - A Systematic Review -
Altayyeb Yousef, Zachary MacDonald, Trevor Simard, Juan J. Russo, Joshua Feder, Michael V. Froeschl, Alexander Dick, Christopher Glover, Ian G. Burwash, Azeem Latib, Josep Rodés-Cabau, Marino Labinaz, Benjamin Hibbert

Vascular Biology and Vascular Medicine

Ca²⁺/Calmodulin-Dependent Protein Kinase II γ-Dependent Serine727 Phosphorylation Is Required for TMEM16A Ca2+-Activated Cl? Channel Regulation in Cerebrovascular Cells
Cai-Xia Lin, Xiao-Fei Lv, Feng Yuan, Xiang-Yu Li, Ming-Ming Ma, Can-Zhao Liu, Jia-Guo Zhou, Guan-Lei Wang, Yong-Yuan Guan

Segmental Difference in Vasoreactivity of the Human Right Gastroepiploic Artery
Takeshi Kinoshita, Masashi Tawa, Tomoaki Suzuki, Tohru Asai, Tomio Okamura

Rapid Communications

Three-Year Follow-up After the Great East Japan Earthquake in the Incidence of Out-of-Hospital Cardiac Arrest With Cardiac Origin
Junya Sado, Kosuke Kiyohara, Taku Iwami, Yuri Kitamura, Emiko Ando, Tetsuya Ohira, Tomotaka Sobue, Tetsuhisa Kitamura

Images in Cardiovascular Medicine

Very Late Strut Overhang on Coronary Angioscopy After Bioresorbable Vascular Scaffold Implantation in a Clinically Stable Patient
Takashi Fujimura, Tomohiro Kawasaki, Takeshi Kimura

Angioscopic Findings of Acute Myocardial Infarction After Kawasaki Disease
Toru Miyoshi, Fumiyasu Seike, Hideo Kawakami, Akira Oshita, Hiroshi Matsuoka

Pyogenic Aortitis - Role of 18F-FDG Positron Emission Tomography/Computed Tomography in Aortic Infection Imaging -
Alejandro Travieso-González, Isidre Vilacosta, David Vivas, Carmen Olmos, Javier Higueras Nafría, María Jesús Pérez Castejón, Aída Ortega Candil, Adela Pelayo Alarcón, Luis Ortega Medina

Clinical Utility of Fractional Flow Reserve on Computed Tomography in Left Main Trunk Disease
Taichi Okonogi, Tomohiro Kawasaki

Protruding In-Stent Mass After Bioresorbable Polymer Sirolimus-Eluting Stent - Ex Vivo Intravascular Imaging and Histopathology -
Rika Kawakami, Takahiro Imanaka, Masaharu Ishihara, Takako Kihara, Kenichi Fujii, Seiichi Hirota, Hiroyuki Hao

Corrigendum

■月刊誌 Circulation Journal Vol.82 No.3 広告掲載企業様一覧
フォシーガ（アストラゼネカ株式会社）
今日の治療指針（株式会社医学書院）
クリアクター、コアテック、タンボコール、ニトロール、ワソラン（エーザイ株式会社）
リピディル（科研製薬株式会社）
アイミクス（大日本住友製薬株式会社）
企業広告（武田薬品工業株式会社）
エリキュース（ブリストル・マイヤーズ・スクイブ株式会社）
ドクターソフト（株式会社油井コンサルティング）
（順不同）

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