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Reviews

Basic Principles of Platelet Biology and Clinical Implications
Dominick J. Angiolillo, Masafumi Ueno, Shinya Goto

・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・597

Potassium Channels and Neurovascular Coupling
Kathryn M. Dunn, Mark T. Nelson

・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・608

Waon Therapy for Cardiovascular Disease
- Innovative Therapy for the 21^st Century -
Masaaki Miyata, Chuwa Tei

・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・617

Editorials

PCI vs CABG in Complicated Diabetic Patients
- Do We Need More Data to Change the Practical Guideline? -
Kee-Sik Kim

・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・622

Long-Term Circulatory Support With a Left Ventricular Assist Device Therapy in Japan
Satoshi Saito, Tomohiro Nishinaka, Kenji Yamazaki

・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・624

S100A8/A9 Complex
- More Than Just a Biomarker of Cardiovascular Risk? -
Kevin Croce

・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・626

Smoking Is a Disease and Smokers Are Patients
Hisayoshi Fujiwara

・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・628

Clinical Significance of Mild Lipid-Lowering by Statins for Prevention of Cardiovascular Disease in Japanese High-Risk Patients
Tetsuro Miyazaki, Hiroyuki Daida

・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・630

Significance of B-Type Natriuretic Peptide Measurement in Patients With Chronic Kidney Disease
Yasunobu Hirata

・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・632

Original Articles

Arrhythmia/Electrophysiology

Protective Effects of Estrogen Against Reperfusion Arrhythmias Following Severe Myocardial Ischemia in Rats
Yan Wang, Qi Wang, Yingnan Zhao, Dezheng Gong, Dongmei Wang, Cong Li, Henan Zhao

・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・634

Risks and Benefits of an Open Irrigation Tip Catheter in Intensive Radiofrequency Catheter Ablation in Patients With Non-Paroxysmal Atrial Fibrillation
Eui-Seock Hwang, Hui-Nam Pak, Sang Weon Park, Jong Sung Park, Boyoung Joung, Donghoon Choi, Moon-Hyoung Lee, Young Hoon Kim

・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・644

Sex-Related Differences in the Risk Factor Profile and Medications of Patients With Atrial Fibrillation Recruited in J-TRACE
Hiroshi Inoue, Takashi Nozawa, Tadakazu Hirai, Shinya Goto, Hideki Origasa, Kazuyuki Shimada, Shinichiro Uchiyama, Takayuki Hirabayashi, Yukihiro Koretsune, Shiro Ono, Tooru Hasegawa, Yasuo Sasagawa, Yoshiaki Kaneko, Yasuo Ikeda for the J-TRACE Investigators

・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・650

Role of Progressive Widening of the Temporal Excitable Gap for Perpetuation of Atrial Fibrillation in the Goat
Zhaoliang Shan, Junjin Yan, Junyan Zhou, Xiangmin Shi, Jianping Guo, Hongtao Yuan, Maurits A. Allessie, Yutang Wang

・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・655

Abnormal Action Potential Duration Restitution Property in the Right Ventricular Outflow Tract in Brugada Syndrome
Sonoko Ashino, Ichiro Watanabe, Masayoshi Kofune, Koichi Nagashima, Kimie Ohkubo, Yasuo Okumura, Toshiko Nakai, Yuji Kasamaki, Atsushi Hirayama

・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・664

Cardiovascular Intervention

A 3-Year Clinical Outcome After Percutaneous Coronary Intervention Using Sirolimus-Eluting Stent and Off-Pump Coronary Artery Bypass Grafting for the Treatment of Diabetic Patients With Multivessel Disease
Ken-ichirou Yamagata, Yu Kataoka, Nobuaki Kokubu, Yoichiro Kasahara, Mitsuru Abe, Hiroyuki Nakajima, Junjiro Kobayashi, Yoritaka Otsuka

・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・671

Impact of High-Responsiveness to Dual Antiplatelet Therapy on Bleeding Complications in Patients Receiving Drug-Eluting Stents
Kengo Tsukahara, Kazuo Kimura, Satoshi Morita, Toshiaki Ebina, Masami Kosuge, Kiyoshi Hibi, Jun Okuda, Noriaki Iwahashi, Nobuhiko Maejima, Tatsuya Nakachi, Fumiyuki Ohtsuka, Katsutaka Hashiba, Yoshio Tahara, Teruyasu Sugano, Satoshi Umemura

・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・679

Anatomical Study of Forearm Arteries With Ultrasound for Percutaneous Coronary Procedures
Zhen-xian Yan, Yu-jie Zhou, Ying-xin Zhao, Zhi-ming Zhou, Shi-wei Yang, Zhi-jian Wang

・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・686

Long-Term Clinical Outcome of Chronic Total Occlusive Lesions Treated With Drug-Eluting Stents
- Comparison of Sirolimus-Eluting and Paclitaxel-Eluting Stents -
Seung-Pyo Lee, Song-Yi Kim, Kyung-Woo Park, Dong-Ho Shin, Hyun-Jae Kang, Bon-Kwon Koo, Jung-Won Suh, Young-Seok Cho, Tae-Jin Yeon, In-Ho Chae, Dong-Ju Choi, Hyo-Soo Kim

・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・693

Comparison of Different Antithrombotic Regimens for Patients With Atrial Fibrillation Undergoing Drug-Eluting Stent Implantation
Fei Gao, Yu Jie Zhou, Zhi Jian Wang, Hua Shen, Xiao Li Liu, Bin Nie, Zhen Xian Yan, Shi Wei Yang, De An Jia, Miao Yu

・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・701

Cardiac Rehabilitation

Effects of Phase III Cardiac Rehabilitation on Mortality and Cardiovascular Events in Elderly Patients With Stable Coronary Artery Disease
Tomo Onishi, Kazunori Shimada, Hiroyuki Sato, Eriko Seki, Yoshiro Watanabe, Satoshi Sunayama, Hirotoshi Ohmura, Yoshiyuki Masaki, Miho Nishitani, Kosuke Fukao, Atsumi Kume, Takahiro Sumide, Hiroshi Mokuno, Hisashi Naito, Sachio Kawai, Hiroyuki Daida

・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・709

Cardiovascular Surgery

Risk Factor Analysis of Long-Term Support With Left Ventricular Assist System
Shunsuke Saito, Goro Matsumiya, Taichi Sakaguchi, Shigeru Miyagawa, Yasushi Yoshikawa, Takashi Yamauchi, Toru Kuratani, Yoshiki Sawa

・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・715

Heart Failure

Left Ventricular Expression of Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 in Failing Rat Hearts
Tomohide Takaya, Hiromichi Wada, Tatsuya Morimoto, Yoichi Sunagawa, Teruhisa Kawamura, Rieko Takanabe-Mori, Akira Shimatsu, Yoshiko Fujita, Yuko Sato, Masatoshi Fujita, Takeshi Kimura, Tatsuya Sawamura, Koji Hasegawa

・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・723

Hypertension and Circulatory Control

Effects of Submaximal Exercise on Blood Rheology and Sympathetic Nerve Activity
Nahoko Ikeda, Takanori Yasu, Ken Tsuboi, Yoshitaka Sugawara, Norifumi Kubo, Tomio Umemoto, Kenshiro Arao, Masanobu Kawakami, Shin-ichi Momomura

・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・730

Imaging

Prospective Electrocardiogram-Gated Axial 64-Detector Computed Tomographic Angiography vs Retrospective Gated Helical Technique to Assess Coronary Artery Bypass Graft Anastomosis
- Comparison of Image Quality and Patient Radiation Dose -
Haruhiko Machida, Ai Masukawa, Isao Tanaka, Rika Fukui, Kazufumi Suzuki, Eiko Ueno, Kojiro Kodera, Kiyoharu Nakano, Yun Shen

・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・735

Ischemic Heart Disease

Enhanced Expression of the S100A8/A9 Complex in Acute Myocardial Infarction Patients
Takashi Katashima, Takahiko Naruko, Fumio Terasaki, Masatoshi Fujita, Kaoru Otsuka, Shougo Murakami, Akira Sato, Michiaki Hiroe, Yoshihiro Ikura, Makiko Ueda, Masaki Ikemoto, Yasushi Kitaura

・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・741

Mycotic DNA in Non-Atherosclerotic Aortic Wall of Coronary Patients Is Associated With sICAM-1 Expression
Bogdan Jegier, Ryszard Jaszewski, Piotr Kurnatowski, Katarzyna Kuba, Malgorzata Lelonek

・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・749

Effect of Vessel Size on Lipid Content of Coronary Plaques Assessed by Integrated Backscatter Intravascular Ultrasound
Young-Guk Ko, Jung-Woo Son, Sang Min Park, Jung-Sun Kim, Donghoon Choi, Myeong-Ki Hong, Yangsoo Jang

・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・754

Molecular Cardiology

Sodium Valproate, a Histone Deacetylase Inhibitor, but Not Captopril, Prevents Right Ventricular Hypertrophy in Rats
Young Kuk Cho, Gwang Hyeon Eom, Hae Jin Kee, Hyung-Seok Kim, Woo-Yeon Choi, Kwang-Il Nam, Jae Sook Ma, Hyun Kook

・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・760

Preventive Medicine

A Randomized Controlled Open Comparative Trial of Varenicline vs Nicotine Patch in Adult Smokers
- Efficacy, Safety and Withdrawal Symptoms (The VN-SEESAW Study) -
Hitomi Tsukahara, Keita Noda, Keijiro Saku

・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・771

Standard-Dose Statin Therapy Provides Incremental Clinical Benefits in Normocholesterolemic Diabetic Patients
Sunao Kojima, Tomohiro Sakamoto, Hisao Ogawa, Akira Kitagawa, Kunihiko Matsui, Hideki Shimomura, Kazuo Kimura, Yasuhiro Ogata, Naritsugu Sakaino on behalf of the Multicenter Study for Aggressive
Lipid-lowering Strategy by HMG-CoA Reductase Inhibitors (MUSASHI) investigators

・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・779

Renal Disease

Relationship Between Renal Dysfunction and Severity of Coronary Artery Disease in Japanese Patients
Arihiro Kiyosue, Yasunobu Hirata, Jiro Ando, Hideo Fujita, Toshihiro Morita, Masao Takahashi, Daisuke Nagata, Takahide Kohro, Yasushi Imai, Ryozo Nagai

・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・786

Plasma B-Type Natriuretic Peptide Level and Cardiovascular Events in Chronic Kidney Disease in a Community-Based Population
Masafumi Sakuma, Motoyuki Nakamura, Fumitaka Tanaka, Toshiyuki Onoda, Kazuyoshi Itai, Kozo Tanno, Masaki Ohsawa, Kiyomi Sakata, Yuki Yoshida, Kazuko Kawamura, Shinji Makita, Akira Okayama

・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・792

Vascular Medicine

Combination Therapy With Olmesartan and Azelnidipine Improves EDHF-Mediated Responses in Diabetic Apolipoprotein E-Deficient Mice
Maki Hosoya, Junko Ohashi, Ayuko Sawada, Aya Takaki, Hiroaki Shimokawa

・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・798

Images in Cardiovascular Medicine

Three-Dimensional Transesophageal Echocardiographic Recognition of Mobile Mass Protruding Into the Left Main Coronary Orifice in a Patient With Aortic Stenosis
Mai Iwataki, Masaaki Takeuchi, Hidetoshi Yoshitani, Nobuhiko Haruki, Kyoko Kaku, Yutaka Otsuji

・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・807

■月刊誌 Circulation Journal Vol.74 No.4 広告掲載企業様一覧
バイアスピリン（バイエル薬品株式会社）
Endeavor（日本メドトロニック）
ガスター（アステラス製薬株式会社）
ラジレス（ノバルティスファーマ株式会社）
FCP8453、FCP7541（フクダ電子株式会社）
全血血小板凝集能測定装置（アイエスケー株式会社）
タナトリル（田辺三菱製薬株式会社）
ルプラック（大正富山医薬品株式会社）
アーチスト（第一三共株式会社）
プロサイリン、リピディル（科研製薬株式会社）
ミリスロール、ミリステープ（日本化薬株式会社）
シグマート（中外製薬株式会社）
グルコバイ（バイエル薬品株式会社）
セイブル（株式会社 三和化学研究所）
プレミネント（万有製薬株式会社）
セララ（ファイザー株式会社）
（順不同）

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