[PR記事]  投薬期間制限解除によりさらに高まるエックスフォージ配合錠への期待
			ARBとCCBの併用は臨床現場で最も汎用されており、投薬期間制限解除を待ち望んでいた臨床医は多い。このたび、使用経験が豊富なバルサルタンとアムロジピンの配合剤であるエックスフォージ配合錠の投薬期間制限が、1年を待たずに解除されることとなった。そこで、エックスフォージ配合錠によせる期待、臨床的意義や特徴、あるいはその位置づけについて専門医の意見を集約した。（さらに詳しく）

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Message From the Editor-in-Chief

Internationalization of the Circulation Journal
Hiroaki Shimokawa

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Reviews

Is There Evidence Supporting Coronary Revascularization in Patients With Left Ventricular Systolic Dysfunction?
Enrico Ammirati, Ornella E. Rimoldi, Paolo G. Camici

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Pathophysiology of Aortic Stenosis and Approach to Treatment With Percutaneous Valve Implantation
Carmen Spaccarotella, Annalisa Mongiardo, Ciro Indolfi

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Vagal Stimulation for Heart Diseases: From Animals to Men
- An Example of Translational Cardiology -
Peter J. Schwartz

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A Decade of Percutaneous Septal Ablation in Hypertrophic Cardiomyopathy
Angelos G. Rigopoulos, Hubert Seggewiss

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Mechanical Circulatory Assistance
- An Evolving Therapy -
J. Raymond Fitzpatrick III, Y. Joseph Woo

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Editorials

Clinical Significance and Impact of "Painless" Acute Aortic Dissection
Hiroshi Matsuo

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Transmural Dispersion of Repolarization and Drug-Induced Torsade de Pointes
- A 3-D Simulation Study -
Tetsushi Furukawa

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Neointimal Coverage Over Coronary Stent Struts Crossing the Side Branch Ostia
Yasuhiko Sakata

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An Old Ventricular Assist Device Still Working for Patients With End-Stage Heart Failure in Japan
Shigeki Morita

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Prediction of Acute Heart Failure Decompensation
Kazuyasu Yoshitani, Yukihito Sato

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Visual vs. Quantitative Assessment
- A New Viewpoint for Cardiac Function Using a Motion Tracking Method -
Kenichi Nakajima

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Original Articles

Aortic Disease

Painless Acute Aortic Dissection
- Diagnostic, Prognostic and Clinical Implications -
Hiroshi Imamura, Yukio Sekiguchi, Tomomi Iwashita, Hiroshi Dohgomori, Katsunori Mochizuki, Kazunori Aizawa, Shin-ichi Aso, Yuichi Kamiyoshi, Uichi Ikeda, Jun Amano, Kazufumi Okamoto

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Arrhythmia/Electrophysiology

Is There a Role for Bi-Atrial Pacing Resynchronisation Therapy in the Management of Drug-Refractory Atrial Fibrillation in Patients Unsuitable for Left Atrial Ablation?
Rajiv Sankaranarayanan, Michael Anthony James, Hanney Gonna, Stephanie Burtchaell, Russell Holloway, Paul Ewings

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Long-Term Clinical Implication of the Occurrence of Dissociated Pulmonary Vein Activities After Circumferential Left Atrial Ablation in Patients With Paroxysmal Atrial Fibrillation
Hongwu Chen, Bing Yang, Weizhu Ju, Fengxiang Zhang, Xiaofeng Hou, Chun Chen, Lishang Zhai, Jing Wang, Kejiang Cao, Minglong Chen, Hung-Fat Tse

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Transmural Dispersion of Repolarization Determines Scroll Wave Behavior During Ventricular Tachyarrhythmias
- A Simulation Study -
Ryo Haraguchi, Takashi Ashihara, Tsunetoyo Namba, Kunichika Tsumoto, Shingo Murakami, Yoshihisa Kurachi, Takanori Ikeda, Kazuo Nakazawa

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Deep Anesthesia Suppresses Ventricular Tachyarrhythmias in Rabbit Model of the Acquired Long QT Syndrome
Hideko Inaba, Noriyuki Hayami, Kosuke Ajiki, Tomoyuki Kunishima, Hidenori Watanabe, Kenta Tsutsui, Noboru Yamagishi, Satoshi Yamagishi, Anna Sugiura, Takashi Mikamo, Yuji Murakawa

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Cardiovascular Intervention

Distal Protection During Primary Coronary Intervention Can Preserve the Index of Microcirculatory Resistance in Patients With Acute Anterior ST-Segment Elevation Myocardial Infarction
Noritoshi Ito, Shinsuke Nanto, Yasuji Doi, Yuma Kurozumi, Daisuke Tonomura, Tomoaki Natsukawa, Hirotaka Sawano, Daisaku Masuda, Shizuya Yamashita, Ken-ichiro Okada, Yasuyuki Hayashi, Tatsuro Kai, Toru Hayashi

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Impact of Cytochrome P450 2C19^*2 Polymorphism on Intra-Stent Thrombus After Drug-Eluting Stent Implantation in Japanese Patients Receiving Clopidogrel
Takahiro Sawada, Toshiro Shinke, Junya Shite, Tomoyuki Honjo, Yoko Haraguchi, Ryo Nishio, Masakazu Shinohara, Ryuji Toh, Tatsuro Ishida, Hiroyuki Kawamori, Amane Kozuki, Takumi Inoue, Hirotoshi Hariki, Ken-ichi Hirata

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Assessment by Optical Coherence Tomography of Stent Struts Across Side Branch
- Comparison of Bare-Metal Stents and Drug-Eluting Stents -
Yong Liu, Toshio Imanishi, Takashi Kubo, Atsushi Tanaka, Hironori Kitabata, Takashi Tanimoto, Yasushi Ino, Hideyuki Ikejima, Hiroto Tsujioka, Kenichi Komukai, Kohei Ishibashi, Manabu Kashiwagi, Yuichi Ozaki, Kumiko Hirata, Masato Mizukoshi, Takashi Akasaka

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Six-Year Clinical Follow-up After Treatment of Diffuse In-Stent Restenosis With Cutting Balloon Angioplasty Followed by Intracoronary Brachytherapy With Liquid Rhenium-188-Filled Balloon via Transradial Approach
Chi-Ling Hang, Bor-Tsung Hsieh, Chiung-Jen Wu, Hon-Kan Yip, Cheng-Hsu Yang, Shyh-Ming Chen, Yuan-Kai Hsieh, Morgan Fu, Sarah Chua, Gary Bih-Fang Guo, Stephen Wan Leung

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Cardiovascular Surgery

Age and Preoperative Total Bilirubin Level Can Stratify Prognosis After Extracorporeal Pulsatile Left Ventricular Assist Device Implantation
Taro Shiga, Koichiro Kinugawa, Masaru Hatano, Atsushi Yao, Takashi Nishimura, Miyoko Endo, Naoko Kato, Yasunobu Hirata, Shunei Kyo, Minoru Ono, Ryozo Nagai

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Heart Failure

Efficacy of Fluid Assessment Based on Intrathoracic Impedance Monitoring in Patients With Systolic Heart Failure
Yoshimitsu Soga, Kenji Ando, Takeshi Arita, Makoto Hyodo, Masahiko Goya, Masashi Iwabuchi, Masakiyo Nobuyoshi

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Hypertension and Circulatory Control

Progression Rate From New-Onset Pre-Hypertension to Hypertension in Korean Adults
Soo Jeong Kim, Jakyoung Lee, Chung Mo Nam, Sun Ha Jee, Il Soo Park, Kyung Jong Lee, Soon Young Lee

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Imaging

Validation of Longitudinal Peak Systolic Strain by Speckle Tracking Echocardiography With Visual Assessment and Myocardial Perfusion SPECT in Patients With Regional Asynergy
Kenya Kusunose, Hirotsugu Yamada, Susumu Nishio, Yukio Mizuguchi, Masahito Choraku, Yasuhiro Maeda, Shinobu Hosokawa, Nobuo Yamazaki, Noriko Tomita, Toshiyuki Niki, Koji Yamaguchi, Kunihiko Koshiba, Takeshi Soeki, Tetsuzo Wakatsuki, Masashi Akaike, Masataka Sata

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Left Ventricular Basal Myocardial Scarring Detected by Delayed Enhancement Magnetic Resonance Imaging Predicts Outcomes After Surgical Therapies for Patients With Ischemic Mitral Regurgitation and Left Ventricular Dysfunction
Koji Takeda, Goro Matsumiya, Seiki Hamada, Taichi Sakaguchi, Shigeru Miyagawa, Takashi Yamauchi, Yoshiki Sawa

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Lipid-Rich Plaques Predict Non-Target-Lesion Ischemic Events in Patients Undergoing Percutaneous Coronary Intervention
- Insights From Integrated Backscatter Intravascular Ultrasound -
Tetsuya Amano, Tatsuaki Matsubara, Tadayuki Uetani, Masataka Kato, Bunichi Kato, Tomohiro Yoshida, Ken Harada, Soichiro Kumagai, Ayako Kunimura, Yusaku Shinbo, Hideki Ishii, Toyoaki Murohara

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Ischemic Heart Disease

Prospective Comparison of the 5 Most Popular Risk Scores in Clinical Use for Unselected Patients With Acute Coronary Syndrome
- Basis for Design of the Banach Score -
Krzysztof J. Filipiak, Lukasz Koltowski, Marcin Grabowski, Grzegorz Karpinski, Renata Glowczynska, Zenon Huczek, Janusz Kochman, Franciszek Majstrak, Grzegorz Opolski

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Molecular Cardiology

Acid-Sensing Ion Channel 3, But Not Capsaicin Receptor TRPV1, Plays a Protective Role in Isoproterenol-Induced Myocardial Ischemia in Mice
Ching-Feng Cheng, I-Lun Chen, Mei-Hsin Cheng, Wei-Shiung Lian, Chao-Chieh Lin, Terry B.J. Kuo, Chih-Cheng Chen

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Peripheral Vascular Disease

Preprocedural Evaluation and Endovascular Treatment of Iliofemoral Artery Disease Without Contrast Media for Patients With Pre-Existing Renal Insufficiency
Daizo Kawasaki, Kenichi Fujii, Masashi Fukunaga, Naohiko Fujii, Motomaru Masutani, Masaaki Lee Kawabata, Takeshi Tsujino, Mitsumasa Ohyanagi, Tohru Masuyama

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Preventive Medicine

High Blood Viscosity Is Closely Associated With Cigarette Smoking and Markedly Reduced by Smoking Cessation
Sayaka Shimada, Koji Hasegawa, Hiromichi Wada, Sachiko Terashima, Noriko Satoh-Asahara, Hajime Yamakage, Shuji Kitaoka, Masaharu Akao, Akira Shimatsu, Yuko Takahashi

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Bilirubin Is Negatively Associated With Hemoglobin A_1c Independently of Other Cardiovascular Risk Factors in Apparently Healthy Japanese Men and Women
Eiji Oda, Ryu Kawai

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Vascular Medicine

Localization of Latent Transforming Growth Factor-β Binding Protein-1 in Human Coronary Atherosclerotic Plaques
Rahmi Öklü, Robin Hesketh, Stephan Wicky, James C. Metcalfe

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Rapid Communication

Effects of Combination Therapy With Warfarin and Bucolome for Anticoagulation in Patients With Atrial Fibrillation
Hiroaki Obata, Hiroshi Watanabe, Masahiro Ito, Satoru Hirono, Haruo Hanawa, Makoto Kodama, Yoshifusa Aizawa

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Controversies in Cardiovascular Medicine

Angiography Is the Gold Standard and Objective Evidence of Myocardial Ischemia Is Mandatory If Lesion Severity Is Questionable
- Indication of PCI for Angiographically Significant Coronary Artery Stenosis Without Objective Evidence of Myocardial Ischemia (Pro) -
Masato Nakamura

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What Can We Expect in PCI in Patients With Chronic Coronary Artery Disease
- Indication of PCI for Angiographically Significant Coronary Artery Stenosis Without Objective Evidence of Myocardial Ischemia (Con) -
Takashi Akasaka

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Images in Cardiovascular Medicine

Atypical Exercise Stress Myocardial Perfusion SPECT Imaging in a Patient With Effort Angina Pectoris
Toshiaki Otsuka, Hideki Miyachi, Chikao Ibuki, Masahiro Toba, Ken-ichi Tokuyama, Kensuke Ishii, Eitaro Kodani, Yoshiki Kusama, Hirotsugu Atarashi, Hiroshi Kishida, Kyoichi Mizuno

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Using Imaging Mass Spectrometry to Accurately Diagnose Fabry's Disease
Kenji Onoue, Nobuhiro Zaima, Yuki Sugiura, Takuya Isojima, Satoshi Okayama, Manabu Horii, Yasuhiro Akai, Shiro Uemura, Genzou Takemura, Hitoshi Sakuraba, Yasuhiro Sakaguchi, Mitsutoshi Setou, Yoshihiko Saito

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Letters to the Editor

Beneficial Actions of Statins in the Reduction of Atrial Fibrillation and Stabilization and Regression of Coronary Plaques: But How and Why?
Undurti N Das

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Beneficial Actions of Statins in the Reduction of Atrial Fibrillation and Stabilization and Regression of Coronary Plaques: But How and Why?
- Reply -
Takeshi Kinoshita, Tohru Asai

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■月刊誌 Circulation Journal Vol.75 No.1 広告掲載企業様一覧
今日の治療指針、治療薬マニュアル（株式会社医学書院）
クリアクター、コアテック、タンボコール、ニトロール、ワソラン（エーザイ株式会社）
サムスカ（大塚製薬株式会社）
プロサイリン、リピディル（科研製薬株式会社）
グルファスト（キッセイ薬品工業株式会社）
リバロ（興和創薬株式会社）
セイブル（株式会社 三和化学研究所）
レザルタス（第一三共株式会社）
アバプロ（大日本住友製薬株式会社）
ルプラック（大正富山医薬品株式会社）
ブロプレス、エカード、ユニシア（武田薬品工業株式会社）
シグマート（中外製薬株式会社）
循環器用製剤（トーアエイヨー株式会社）
エックスフォージ（ノバルティスファーマ株式会社）
ラジレス（ノバルティスファーマ株式会社）
ミリスロール、ミリステープ（日本化薬株式会社）
ミカムロ（日本ベーリンガーインゲルハイム株式会社）
ノルバスク（ファイザー株式会社）
VS-1500E、ＦＭ１９０（フクダ電子株式会社）
エパデール（持田製薬株式会社）
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